120-year-old challenge championed by chemists creating new compound

Scientists have discovered the mechanism of creating a reactive chemical compound after more than 100 years. Molecules known as N-heteroarenes are ring-shaped compounds containing nitrogen atoms. According to the study they are key elements of pharmaceuticals, agrochemicals, and materials.

But they are difficult for chemists to synthesize and manipulate. The reason is five-membered N-Heteroarynes effectively and the presence of the triple bond that leads to increased reactivity and instability.

One of the authors Courtney Roberts highlighted their presence and importance in various aspects. However, the process of creation is a decades-long challenge for chemists. The main obstacle is their very high reactivity. They are so active that even chemists used computer modeling to predict that they would be impossible to make.

Overcoming a 100-year-long reactive challenge 

That’s why the research required collaboration between organic and inorganic chemists to try to achieve progress with an innovative approach. The scientists experimented in a controlled environment. It means they removed reactive elements such as oxygen, to avoid at least part of the reactive challenges.

They were able to drive these chemical reactions with specialized equipment. Also, they were able to get rid of elements that are normally found in our atmosphere, explained Jenna Humke. “Fortunately, we have the tools to do that at the University of Minnesota. We performed the experiments under nitrogen in a sealed glove box,” she said.  As noted that creates an inactive environment for testing and moving samples.

Interdisciplinary approach toward better future

These experiments were accomplished with the help of organometallic catalysis. Organometallic catalysis has revolutionized how chemists conceive organic synthesis. The use of transition metals as catalysts has allowed chemical transformations that otherwise would not be feasible. Also, it has been utilized in numerous industrial processes.

In the statement, Roberts emphasized the importance of an interdisciplinary approach. That approach had a key role in overcoming the long-standing challenge. “These unique nitrogen-containing molecules have widespread applications in all aspects of human life,” said Roberts.

The plan is to make it available to chemists. Also, to make it available in more areas and to simplify the process of its creation. This means possible new medicines, safer agricultural products, and better electronics for us.

N-Heteroaromatics are compounds that contain nitrogen atoms within their ring structures. These compounds are used in pharmaceuticals, agrochemicals, and other fields due to their diverse chemical properties and biological activities. N-Heteroarynes are a subclass of heterocyclic compounds containing a triple bond and at least one nitrogen atom within the ring structure. As previously mentioned these compounds are highly reactive. N-Heteroarynes are valuable intermediates in organic synthesis and have potential applications in medicinal chemistry.

N-Heteroarenes incorporation into drug molecules imparts specific functionalities and interactions that are crucial for biological activity. For example, in antiviral drugs that are often used as antiviral agents to treat viral infections. Also, in drugs that used to treat psychiatric disorders, such as depression and schizophrenia.  Their chemical functionalities, coupled with their ability to interact with biological targets, make them invaluable tools for developing life-saving medications.